Which intermediates should we make? - OSM at Federation Uni

[david1597]

Hi All, I worked with @mattodd and the Sydney team on OSM for 12 months in 2017-2018. I am back in a position to contribute to OSM again, now as a lecturer at Federation University in Australia.

It'll be the undergraduates making the contribution, initially, our third year students who are taking an organic synthesis for drug design course. In previous years they have made simple compounds during their lab component. This year we'd like them to use the same skills and techniques but make something that is ultimately useful to someone. OSM should be perfect. With time and other constraints I think final novel compounds are out of reach in this instance, but common intermediates that others could put to use would be great.

Are there any intermediate compounds from series 4, that are of current interest, and currently needed by anyone? The compounds would be ready by mid-April. We can send them on wherever they are required. Any ideas @maratsydney or others currently in the lab working on this? I'll make a quick post over in the mycetoma repo too in case efforts would be better placed on that project.

[alintheopen]

Hi @david1597 - this would be great :) I'm hoping to arrange a Skype meeting in early Feb to talk about different targets for schools and undergraduates in Mycetoma, Malaria, TB and overpriced medicines and we will have a new postdoc starting in March who will be able to help with coordination too. @mattodd would early/mid Feb be a good time for you too? I will start a GitHub post to gather thoughts/contributions too. Alice

[brichcja]

Hello folks - I'm new here, but many years ago I shared undergrad supervisions with @mattodd. Nowadays I'm at the Uni of Bristol in the UK, and run our teaching labs. Much like @david1597 above, I'm wondering about getting 3rd year UGs to make stuff for the project, though this would be next academic year (from October). So, if you're talking about this, can I join in? Chris

[MFernflower]

I don't think mycetoma project needs any intermediates - 3‐(4‐chloro‐2‐fluorobenzoyl)pyridine could be nice to have a few grams of for the project however

@david1597 @brichcja @fantasy121

[alintheopen]

Hi @brichcja and @david1597 and @mattodd could we possibly Skype later this week Thurs/Fri 13/14 or early the following week?

Alice

[bendndi]

I don't think mycetoma project needs any intermediates - 3‐(4‐chloro‐2‐fluorobenzoyl)pyridine could be nice to have a few grams of for the project however

@david1597 @brichcja @fantasy121

I've just posted some thoughts on the MycetOS intermediate over on MycetOS

[bendndi]

I don't think mycetoma project needs any intermediates - 3‐(4‐chloro‐2‐fluorobenzoyl)pyridine could be nice to have a few grams of for the project however

@david1597 @brichcja @fantasy121

I've just posted some thoughts on the MycetOS intermediate over on MycetOS

[bendndi]

@alintheopen @mattodd @david1597 @brichcja

Appreciate this may be a bit forward of me but I'd be happy to join any call you have regarding the UG / student approaches to OSM. As you know we have similar approach at DNDi and we're currently branching out into some new projects, it would be really interesting to hear how things are going from your side and perhaps update you on where we are :-)

[david1597]

Yes I'm good for a Skype meeting. Either Thur/Fri, or Mon/Tue next week should work. @alintheopen @mattodd @brichcja @bendndi

[MFernflower]

All mycetoma related intermediate compound discussion is at OpenSourceMycetoma/Series-1-Fenarimols#26 We will need to do same with malaria or tb compounds

[brichcja]

Yes, I can skype. When do we have in mind?

[MFernflower]

@mattodd could you upload recording to opensourcemalaria youtube?

[alintheopen]

Mon/Tue/Thurs/Fri next week would be great for me if possible? Early is tricky at the moment but looks like 6-10pm Aus time are quite sociable for Switzerland and UK/

Hung may like to join and we also have two new postdocs and a new honours student in the group who might join too!