Unexpected isomerization of oxetane-carboxylic acids

[mattodd]

Interesting preprint from Enamine. They cite our bioisostere paper, @edwintse, as an example of such compounds being used as starting materials. Any issues we ought to consider?

[edwintse]

Hmm interesting. I believe in our case it's ok. I did the reduction of the acid then the SNAr. If it was the lactone that coupled then the mass of the final compound would be different. I don't have the acid reagent anymore (it was done in Syd) but it would be interesting to check what it looks like now 🤔