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Hi @kant@flying-sheep@ostegle@vals@NickEngland , thanks for your contribution to SpatialDE! I'm facing a bug when I run resid_expr = NaiveDE.regress_out(adata.obs[['total_counts']], norm_expr.T, 'np.log(total_counts)') . This produces an error LinAlgError: SVD did not converge in Linear Least Squares. I have checked that there is no NA and Infinite numbers in norm_expr.