Meaning of negative signature scores

[alievakrash]

Hello,
I am trying the VISION package to estimage the score on scRNA seq data of some signature that I pull out. My signature has both positive and negative genes, so is a signed signature. However at the end I only get a combined signature with negative values, these range from -0.1 to -0.5, so I can still see differences between populations, but it is not clear to me what it means biologically. Does it mean that only downregulated genes are different between cells, and that the upregulated ones have no effect ?

Cheers