Measuring the deleteriousness of missense and nonsense mutations using the structurally resolved human protein interactome

Scripts for building human structural interactomes from human binary protein–protein interactions (PPIs), mapping missense and nonsense mutations onto the structural interactomes, and predicting the 'edgotypes' (edge-specific or PPI-specific perturbations) of missense mutations. Such analyses allow for a comprehensive comparison of the functional implications and deleteriousness of missense and nonsense mutations.

Citation

Su, T.-Y., & Xia, Y. (2025). A quantitative comparison of the deleteriousness of missense and nonsense mutations using the structurally resolved human protein interactome. Protein Science, 34(6), e70155.

Installation/Usage

Python 3 is required.

1. Clone or download this repository

2. Navigate to the downloaded MutDeleteriousness folder

$ cd MutDeleteriousness

3. Install the Python packages listed in requirements.txt

$ pip3 install -r requirements.txt

4. Follow the instructions and run the scripts listed in instructions.bash

Contact

Ting-Yi Su [email protected]